http://obigriffith.github.io/

Professional Preparation

Ph.D. in Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada, 2003–2008

Molecular Biology Graduate Exchange, Simon Fraser University, Burnaby, BC, Canada, 2003-2004

B.Sc. in Biology (Honours) and Biochemistry, University of Winnipeg, Winnipeg, MB, Canada, 1996-2002

 
Selected Publications

Griffith M*,†, Spies NC*, Krysiak K*, Coffman AC, McMichael JF, Ainscough BJ, Rieke DT, Danos AM, Kujan L, Ramirez CA, Wagner AH, Skidmore ZL, Liu CJ, Jones MR, Bilski RL, Lesurf R, Barnell EK, Shah NM, Bonakdar M, Trani L, Matlock M, Ramu A, Campbell KM, Spies GC, Graubert AP, Gangavarapu K, Eldred JM, Larson DE, Walker JR, Good BM, Wu C, Su AI, Dienstmann R, Jones SJM, Bose R, Spencer DH, Wartman LD, Wilson RK, Mardis ER, Griffith OL†. 2016. CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer. Nature Genetics.

Fu X, Jeselsohn R, Pereira R, Hollingsworth EF, Creighton CJ, Li F, Shea M, Nardone A, De Angelis C, Heiser LM, Anur P, Wang N, Grasso CS, Spellman P, Griffith OL, Tsimelzon A, Gutierrez C, Huang S, Edwards DP, Trivedi MV, Rimawi MF, Lopez-Terrada D, Hilsenbeck SG, Gray JW, Brown M, Osborne CK, Schiff R. 2016. FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer. Proceedings of the National Academy of Sciences.


Griffith OL*, Chan SR*, Griffith M, Krysiak K, Skidmore ZL, Hundal J, Allen JA, Arthur CD, Runci D, Bugatti M, Miceli AP, Schmidt H, Trani L, Kanchi KL, Miller CA, Larson DE, Fulton RS, Vermi W, Wilson RK, Schreiber RD, Mardis ER. 2016. Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas. Cell Reports.

Ainscough BJ, Griffith M†, Coffman AC, Wagner AH, Kunisaki J, Choudhary MNK, McMichael JF, Fulton RS, Wilson RK, Griffith OL†, Mardis ER. 2016. DoCM: a database of curated mutations in cancer. Nature Methods.


Miller CA, Gindin Y, Lu C, Griffith OL, Griffith M, Shen D, Hoog J, Li T, Larson DE, Watson M, Davies SR, Hunt K, Suman V, Snider J, Walsh T, Colditz GA, Katherine DeSchryver K, Wilson RK, Mardis ER, Ellis MJ. 2016. Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers. Nature Communications.

Hundal J, Carreno BM, Petti AA, Linette GP, Griffith OL, Mardis ER, Griffith M. 2016. pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens. Genome Medicine.

Griffith M†, Walker JR, Spies N, Ainscough BJ, Griffith OL†. 2015. Informatics for RNA-seq: A web resource for analysis on the cloud. PLoS Computational Biology.

Kumar RD, Searleman AC, Swamidass SJ, Griffith OL, Bose R. 2015. Statistically Identifying Tumor Suppressors and Oncogenes from Pan-Cancer Genome Sequence Data. Bioinformatics.

Griffith M*,†, Griffith OL*,†, Smith SM*, Ramu A, Callaway MB, Brummett AM, Kiwala M, Coffmann AC, Regier AA, Oberkfell BJ, Sanderson GE, Mooney TP, Nutter N, Belter EA, Du F, Long RL, Abbott TE, Ferguson I, Morton D, Burnett M, Weible JV, Peck JB, Dukes A, McMichael JF, Lolofie JT, Derickson BR, Hundall J, Skidmore ZL, Ainscough BJ, Dees ND, Schierding WS, Kandoth C, Kim K, Lu C, Harris CC, Maher N, Maher CA, Magrini VJ, Abbott BS, Chen K, Clark E, Das I, Fan X, Hawkins AE, Hepler TG, Wylie TN, Leonard S, Schroeder WE, Shi X, Carmichael KL, Weil M, Wohldstadter RW, Stiehr G, McLellan MD, Pohl CS, Miller CA, Koboldt DC, Walker JR, Eldred JM, Larson DE, Dooling DJ, Ding L, Mardis ER, Wilson RK. 2015. Genome Modeling System: A Knowledge Management Platform for Genomics. PLoS Computational Biology.

Juric D*, Castel P*, Griffith M, Griffith OL, Won HH, Ellis H, Ebbesen S, Ainscough BJ, Ramu A, Iyer G, Shah RH, Huynh T, Mino-Kenudson M, Sgroi D, Isakoff S, Thabet A, Elamine L, Quadt C, Peters M, Huang A, Mardis ER, Solit D, Lowe S, Berger MF, Baselga J, Scaltriti M. 2015. Convergent loss of PTEN leads to clinical resistance to a PI3K-alpha inhibitor. Nature.

Good BM, Ainscough BJ, McMichael JF, Su AI†, Griffith OL†. 2014. Organizing knowledge to personalize medicine in cancer. Genome Biology.

Miller CA, White BS, Dees ND, Griffith M, Griffith OL, Welch JS, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, Wilson RK, Ding L. 2014. SciClone: Inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution. PLoS Computational Biology.

Griffith M*,†, Griffith OL*,†, Coffman AC, Weible JV, McMichael JF, Spies NC, Koval J, Das I, Callaway MB, Eldred JM, Miller CA, Subramanian J, Govindan R, Kumar RD, Bose R, Ding L, Larson DE, Dooling DJ, Smith SM, Ley TJ, Mardis ER, Wilson RK. 2013. DGIdb – Mining the druggable genome for personalized medicine. Nature Methods.

Daemen A*,†, Griffith OL*,†, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson E, van’t Veer LJ, Spellman PT, Gray JW. 2013. Modeling precision treatment of breast cancer. Genome Biology.

Griffith M, Griffith OL, Mwenifumbo J, Morin RD, Goya R, Tang MJ, Hou Y, Pugh TJ, Robertson G, Chittaranjan S, Ally A, Asano JK, Chan SY, Li HI, McDonald H, Teague K, Zhao Y, Zeng T, Delaney A, Hirst M, Morin GB, Jones SJM, Tai IT, Marra MA. 2010. Alternative expression analysis by RNA sequencing. Nature Methods.

Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, Paul JE, Boyle M, Woolcock BW, Kuchenbauer F, Yap D, Humphries RK, Griffith OL, Shah S, Zhu H, Kimbara M, Shashkin P, Charlot JF, Tcherpakov M, Corbett R, Tam A, Varhol R, Smailus D, Moksa M, Zhao Y, Delaney A, Qian H, Birol I, Schein J, Moore R, Holt R, Horsman DE, Connors JM, Jones S, Aparicio S, Hirst M, Gascoyne RD, Marra MA. 2010. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nature Genetics.

Griffith M, Tang MJ, Griffith OL, Chan SY, Asano JK, Zeng T, Flibotte S, Ally A, Baross A, Morin RD, Hirst M, Jones SJM, Morin GB, Tai IT and Marra MA.  2008. ALEXA – A microarray design platform for alternative expression analysis. Nature Methods.

Griffith OL*,†, Montgomery SB*,†, Bernier B, Chu B, Kasaian K, Aerts S, Mahony S, Sleumer MC, Bilenky M, Haeussler M, Griffith M, Gallo SM, Giardine B, Hooghe B, Van Loo P, Blanco E, Ticoll A, Lithwick S, Portales-Casamar E, Donaldson IJ, Robertson G, Wadelius C, De Bleser P, Vlieghe D, Halfon MS, Wasserman W, Hardison R, Bergman CM, Jones SJ; Open Regulatory Annotation Consortium. 2008. ORegAnno: an open-access community-driven resource for regulatory annotation. Nucleic Acids Research.

Robertson G, Hirst M, Bainbridge M, Bilenky M, Zhao Y, Zeng T, Euskirchen G, Bernier B, Varhol R, Delaney A, Thiessen N, Griffith OL, He A, Marra M, Snyder M and Jones S. 2007. Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nature Methods